OSQAM: Online Service for quality monitoring of 3D-brain-on-chip and Alzheimer’s Disease Model
During the project, sixteen 3D-brain-on-chip devices, each having six chambers, were produced. On these devices, organoids were cultivated in the chambers. At different stages/times of this cultivation process, several thousand microscopic images were taken. These images were used to develop and evaluate a fully-automated image analysis algorithm based on artificial intelligence. This algorithm is provided via the online platform IKOSA (www.ikosa.ai) in order to offer a worldwide available service for quality monitoring for the organoids.
The project partners target the pharma R&D market, who can speed up drug R&D for neurodegenerative diseases. Within this project, NORGANOID significantly improved the quality of their chip design while KML Vision developed new image analysis modules for their online platform IKOSA. The combination of these achievements facilitates the usage of standardized samples in drug research, e.g. for the development of treatments for Alzheimer’s Disease, and makes this procedure much more efficient.